Public lecture by Nobel Prize Winner Brian Kobilka “Structural insights into G protein coupled receptor activation” (Vilnius)
Event date: 26 September
G protein coupled receptors (GPCRs) conduct the majority of cellular responses to hormones and neurotransmitters, and are therefore the largest group of pharmaceutical targets for a broad spectrum of diseases. The goal of prof. B. Kobilka’s research over the past 25 years has been to characterize the structure and mechanism of activation of GPCRs. The scientists have applied a spectrum of biochemical and biophysical tools to study different aspects of GPCR structure and activation. Nobel Prize winner will discuss what these studies have taught about allosteric regulation of GPCR structure and function by G proteins and ligands. He will also discuss challenges in GPCR drug discovery, and the potential impact of structural biology and other scientific advances on future drug discovery efforts.
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